Evaluation of the Microbiological Activity of Myracrodruon urundeuva Allemão Extract Against Clinically Relevant Pathogens
Guilherme F. Teixeira1, Damiana G. de Sousa Freitas1, Severino D. Gonçalves de Sousa2, Paula P. Marques Cordeiro1, Luís P.-de-Morais1, José Weverton Almeida-Bezerra1*, Mariana P. da Silva1, Gabriel de O. Lôbo3, Darlyane P. do Nascimento4, Regivânia L. Silva1, Raniere R. da Silva1, Simone G. de Sousa1, Anita O. B. Pereira Bezerra Martins1, João P. da Silva Junior1, Deivyson B. Leite da Cunha5, Maria E. Paulino da Silva6, Antonio R. Camilo Alcantara1, Maria Bethânia de S. Ferreira Braga7, Alessandro M. Ribeiro8, Adrielson J. da Silva1, João A. de Oliveira Borges1, Henrique D. Melo Coutinho1, Carlos A. Leite dos Santos9, Maria H. Garcia Novais9
1Regional University of Cariri, Crato – CE, Brazil.
2Federal University of Mato Grosso, Cuiaba – MT, Brazil.
3Cecape College, Juazeiro do Norte – CE, Brazil.
4Dr. Lea o Sampaio University Center, Juazeiro do Norte – CE, Brazil.
5Federal University of Paraí ba, Joa o Pessoa -PB, Brazil.
6Federal University of Pernambuco, Recife – PE, Brazil.
7Esta cio School of Medicine in Juazeiro do Norte – Juazeiro do Norte – CE, Brazil.
8Federal University of Bahia, Vito ria da Conquista – BA, Brazil.
9Federal University of Cariri – Crato – CE, Brazil.
*Corresponding Author: Prof. Dr. Jose Weverton Almeida-Bezerra, Department of Biological Chemistry, Regional University of Cariri, 63105-000, Crato, CE, Brazil.
https://doi.org/10.58624/SVOAMB.2025.06.011
Received: April 08, 2025
Published: May 12, 2025
Citation: Teixeira GF, de Sousa Freitas DG, Gonçalves de Sousa SD, Marques Cordeiro PP, P.-de-Morais L, Almeida-Bezerra JW, da Silva MP, de O. Lo bo G, do Nascimento DP, Silva RL, da Silva RR, de Sousa SG, Pereira Bezerra Martins AOB, da Silva Junior JP, Leite da Cunha DB, Paulino da Silva ME, Camilo Alcantara AR, Ferreira Braga MB de S, Ribeiro AM, da Silva AJ, de Oliveira Borges JA, Melo Coutinho HD, Leite dos Santos CA, Garcia Novais MH. Evaluation of the Microbiological Activity of Myracrodruon urundeuva Allema o Extract Against Clinically Relevant Pathogens. SVOA Microbiology 2025, 6:3, 85-93. doi:10.58624/SVOAMB.2025.06.011
Abstract
Antimicrobial resistance is a global concern, affecting public health and generating economic and social impacts, which requires global strategies to contain its spread and reduce associated deaths. Medicinal plants demonstrate efficacy against pathogenic microorganisms, offering alternatives in the fight against microbial resistance. As a highlight, Casearia javitensis has antimicrobial and antiparasitic properties of therapeutic relevance to cope with these microorganisms. This research aimed to evaluate the antibacterial activity of ethanolic extract of C. javitensis leaves (EECJ), as well as its antibiotic potentiating activity. Leaves of the species were collected, dried, crushed and subjected to extraction using ethanol. For the antimicrobial assays, conventional and multidrug-resistant bacterial (MDR) strains were used. The inhibition capacity was analyzed by means of the Minimum Inhibitory Concentration (MIC), at concentrations from 0.5 to 512 μg/mL. The potentiating activity was evaluated using subinhibitory concentrations of EECJ (MIC/8) in association with the antibiotic’s gentamicin, ampicillin and norfloxacin. The data obtained was submitted to statistical analysis. The results indicated that EECJ did not present isolated antibacterial activity (MIC > 512 μg/mL); however, it has been shown to be effective as an antibiotic enhancer, reducing the MIC of gentamicin, ampicillin, and norfloxacin against the MDR strains of E. coli, S. aureus, and P. aeruginosa. These findings suggest that ethanolic extract of C. javitensis may be a promising alternative in combination therapies.
Keywords: Bacterial Resistance, Aroeira-do-sertão, Phytochemicals, Flavonoids, and Catechins
